| Molecular Therapy | 2025 | Research Group: CHEN Haiyong |
CPOS Support |
| C-reactive protein promotes diabetic kidney disease via Smad3-mediated NLRP3 inflammasome activation | Confocal Microscopy | ||
| PMID: 39539016 | DOI: 10.1016/j.ymthe.2024.11.018 | ||
| BRAIN | 2025 | Research Group: CHUNG Hon Yin Brian |
CPOS Support |
| De novo and inherited variants in DDX39B cause a novel neurodevelopmental syndrome | RNA Sequencing | ||
| PMID: 39918047 | DOI: 10.1093/brain/awaf035 | ||
| Nature | 2024 | Research Group: NI Tao, YUAN Shuofeng | CPOS Support |
| Molecular architecture of coronavirus double-membrane vesicle pore complex | Cryo-Electron Microscopy
High-Performance Computing Server LC-MS/MS |
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| PMID: 39143215 | DOI: 10.1038/s41586-024-07817-y | ||
| Cell Metabolism | 2024 | Research Group: LING Guang Sheng Heidi | CPOS Support |
| Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes | GC-MS/MS | ||
| PMID: 39488214 | DOI: 10.1016/j.cmet.2024.10.004 | ||
| Nature Biomedical Engineering | 2024 | Research Group: WONG Siu Lun Alan | CPOS Support |
| High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 | Flow Cytometry
Next Generation Sequencing |
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| PMID: 37996617 | DOI: 10.1038/s41551-023-01140-z | ||
| Cancer Communications | 2024 | Research Group: YAM Wai Ping Judy | CPOS Support |
| NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma | In Vivo Imaging Confocal Microscopy |
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| PMID: 38152992 | DOI: 10.1002/cac2.12515 | ||
| Nature Communications | 2024 | Research Group: ZHOU Jie | CPOS Support |
| Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction | Confocal Microscopy Flow Cytometry |
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| PMID: 39738014 | DOI: 10.1038/s41467-024-55076-2 | ||
| Nature Communications | 2024 | Research Group: HUANG Yuanhua | CPOS Support |
| Robust analysis of allele-specific copy number alterations from scRNA-seq data with Xclone | Next-Generation Sequencing (WES)
Single Cell Analysis |
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| PMID: 39107346 | DOI: 10.1038/s41467-024-51026-0 | ||
| Nature Communications | 2024 | Research Group: DENG Wuguo | CPOS Support |
| FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity | NPC Tissue Bank | ||
| PMID: 38816360 | DOI: 10.1038/s41467-024-48397-9 | ||
| Advanced Science | 2024 | Research Group: LAI Sau Wan Cora | CPOS Support |
| Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep | Two-photon Imaging | ||
| PMID: 39382074 | DOI: 10.1002/advs.202400662 | ||
| Advanced Science | 2024 | Research Group: YAM Wai Ping Judy | CPOS Support |
| The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma | LC-MS/MS
Flow Cytometry |
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| PMID: 38528665 | DOI: 10.1002/advs.202306059 | ||
| Hepatology | 2024 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| DGKH-mediated phosphatidic acid oncometabolism as a driver of self-renewal and therapy resistance in HCC | Flow Cytometry Animal Imaging Confocal Microscopy |
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| PMID: 39663958 | DOI: 10.1097/HEP.0000000000001158 | ||
| Nature Structural & Molecular Biology | 2024 | Research Group: TI Shih Chieh Jeff | CPOS Support |
| Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets | Fluorescence Microscopy | ||
| PMID: 39496813 | DOI: 10.1038/s41594-024-01406-3 | ||
| Clin Cancer Res | 2024 | Research Group: IP Pun Ching Philip | CPOS Support |
| Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair-Deficient Uterine Leiomyosarcoma | Next-Generation Sequencing
(WES, RNA-seq) |
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| PMID: 38848043 | DOI: 10.1158/1078-0432.CCR-23-3720 | ||
| Molecular Cancer | 2023 | Research Group: CHAN W David | CPOS Support |
| Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis | LC-MS/MS | ||
| PMID: 36624516 | DOI: 10.1186/s12943-022-01703-9 | ||
| Signal Transduction and Targeted Therapy | 2023 | Research Group: SUGIMURA Ryohichi | CPOS Support |
| Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis | FACS
ScRNA-seq |
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| PMID: 37264003 | DOI: 10.1038/s41392-023-01455-y | ||
| Gut | 2023 | Research Group: YAN Hoi Ning Helen |
CPOS Support |
| Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models | RNA Sequencing
Whole Exome Sequencing |
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| PMID: 35705367 | DOI: 10.1136/gutjnl-2022-327121 | ||
| Nature Cancer | 2023 | Research Group: MAK Tak Wah |
CPOS Support |
| Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma | Partek Flow | ||
| PMID: 37640929 | DOI: 10.1038/s43018-023-00624-w | ||
| Blood | 2023 | Research Group: LEUNG Yu Hung Anskar |
CPOS Support |
| Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML | Flow Cytometry
RNA Sequencing |
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| PMID: 37738460 | DOI: 10.1182/blood.2023019782 | ||
| ACS Nano | 2023 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation | RNA Sequencing | ||
| PMID: 37966480 | DOI: 10.1021/acsnano.3c01199 | ||
| Nature Communications | 2023 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma | Confocal Microscopy Flow Cytometry |
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| PMID: 38030644 | DOI: 10.1038/s41467-023-43670-9 | ||
| Nature Communications | 2023 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer | Confocal Microscopy
Flow Cytometry Lipidomics Analysis Next Generation Sequencing |
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| PMID: 37208334 | DOI: 10.1038/s41467-023-38581-8 | ||
| Nature Communications | 2023 | Research Group: LEUNG Wai Keung | CPOS Support |
| Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori | Biobank
DNA Extraction Next Generation Sequencing |
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| PMID: 37069161 | DOI: 10.1038/s41467-023-37975-y | ||
| Nature Communications | 2023 | Research Group: GUAN Xin Yuan | CPOS Support |
| Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction | Single-cell Analysis
Next Generation Sequencing GC-MS/MS |
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| PMID: 37024479 | DOI: 10.1038/s41467-023-37614-6 | ||
| Advanced Science | 2023 | Research Group: YAM Wai Ping Judy | CPOS Support |
| Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma | Animal Imaging Confocal Microscopy Proteomic Profiling |
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| PMID: 37387563 | DOI: 10.1002/advs.202302677 | ||
| Advanced Science | 2023 | Research Group: CHEUNG Martin | CPOS Support |
| Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury | Confocal Imaging | ||
| PMID: 37296073 | DOI: 10.1002/advs.202205804 | ||
| Journal of the American Chemical Society | 2023 | Research Group: TANNER Julian Alexander | CPOS Support |
| Directed Evolution of a G-Quadruplex Peroxidase DNAzyme and Application in Proteomic DNAzyme–Aptamer Proximity Labeling | LC-MS/MS | ||
| PMID: 37276197 | DOI: 10.1021/jacs.3c02625 | ||
| Nucleic Acids Research | 2023 | Research Group: JAUCH Ralf | CPOS Support |
| Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17 | Single-cell Analysis
Confocal Imaging |
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| PMID: 37607832 | DOI: 10.1093/nar/gkad597 | ||
| Hepatology | 2023 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling | Flow Cytometry Animal Imaging Confocal Microscopy |
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| PMID: 36630996 | DOI: 10.1097/HEP.0000000000000269 | ||
| Science Advances | 2023 | Research Group: JAUCH Ralf | CPOS Support |
| An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming | Single-cell Analysis
Confocal Imaging |
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| PMID: 37611093 | DOI: 10.1126/sciadv.adh2501 | ||
| Proceedings of the National Academy of Sciences | 2023 | Research Group: ZHOU Jie | CPOS Support |
| Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants | Confocal Imaging
Flow Cytometry |
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| PMID: 37068258 | DOI: 10.1073/pnas.2300376120 | ||
| Cell Systems | 2023 | Research Group: WONG Siu Lun Alan | CPOS Support |
| Parallel engineering and activity profiling of a base editor system | Cell Sorting
Flow Cytometry Next Generation Sequencing |
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| PMID: 37164010 | DOI: 10.1016/j.cels.2023.03.007 | ||
| Hypertension | 2023 | Research Group: LAU Kui Kai | CPOS Support |
| Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring | DNA Extraction
Next Generation Sequencing |
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| PMID: 37073724 | DOI: 10.1161/HYPERTENSIONAHA.122.20752 | ||
| Nature Medicine | 2022 | Research Group: PEIRIS Malik | CPOS Support |
| Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination | Mycoplasma Testing | ||
| PMID: 35051989 | DOI: 10.1038/s41591-022-01704-7 | ||
| Signal Transduction and Targeted Therapy | 2022 | Research Group: ZHOU Jie | CPOS Support |
| Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids | Confocal Microscopy | ||
| PMID: 36529763 | DOI: 10.1038/s41392-022-01247-w | ||
| Journal of Hepatology | 2022 | Research Group: YAM Wai Ping Judy | CPOS Support |
| Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma |
Confocal Microscopy LC-MS/MS |
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| PMID: 34922977 | DOI: 10.1016/j.jhep.2021.12.005 | ||
| Gut | 2022 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression | Single-cell RNA-seq | ||
| PMID: 34588223 | DOI: 10.1136/gutjnl-2021-324321 | ||
| Emerging Microbes & Infections | 2022 | Research Group: WOO Chiu Yat Patrick | CPOS Support |
| Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles | LC–MS/MS | ||
| PMID: 35786393 | DOI: 10.1080/22221751.2022.2098058 | ||
| Emerging Microbes & Infections | 2022 | Research Group: POON Lit Man Leo | CPOS Support |
| Recombinant BA.1/BA.2 SARS-CoV-2 Virus in Arriving Travelers, Hong Kong, February 2022 | Next Generation Sequencing (Amplicon Seq) | ||
| PMID: 35394420 | DOI: 10.3201/eid2806.220523 | ||
| Nucleic Acids Research | 2022 | Research Group: WONG Siu Lun Alan | CPOS Support |
| High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination | Flow Cytometry | ||
| PMID: 35051997 | DOI: 10.1093/nar/gkab1291 | ||
| Nature Communications | 2022 | Research Group: WONG Chak Lui Carmen | CPOS Support |
| Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer | Flow Cytometry | ||
| PMID: 35177645 | DOI: 10.1038/s41467-022-28618-9 | ||
| Nature Communications | 2022 | Research Group: WONG Siu Lun Alan | CPOS Support |
| Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities | Cell Sorting
Flow Cytometry |
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| PMID: 35468907 | DOI: 10.1038/s41467-022-29874-5 | ||
| Advanced Science | 2022 | Research Group: WONG Sze Tsai Alice | CPOS Support |
| A Selective β-Catenin-Metadherin/CEACAM1-CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor-Macrophage Interaction | Next Generation Sequencing (RNA Seq) | ||
| PMID: 35403834 | DOI: 10.1002/advs.202103230 | ||
| Advanced Science | 2022 | Research Group: CHEUNG Martin | CPOS Support |
| DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3 | Animal Imaging
Confocal Microscopy LC-MS/MS |
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| PMID: 35088579 | DOI: 10.1002/advs.202105226 | ||
| Cell Reports Medicine | 2022 | Research Group: LIU Pentao | CPOS Support |
| Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection | Flow Cytometry | ||
| PMID: 36495872 | DOI: 10.1016/j.xcrm.2022.100849 | ||
| Genome Medicine | 2022 | Research Group: WONG Wing Hon Jason | CPOS Support |
| Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies. |
Next Generation Sequencing (WGS) LC-MS/MS |
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| PMID: 36316687 | DOI: 10.1186/s13073-022-01131-w | ||
| eBioMedicine | 2022 | Research Group: LUNG Li Maria | CPOS Support |
| Epigenomic landscape study reveals molecular subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma |
Bisulfite Pyrosequencing |
||
| PMID: 36371985 | DOI: 10.1016/j.ebiom.2022.104357 | ||
| Cell Reports | 2022 | Research Group: CHEUNG Wai Ting Lydia | CPOS Support |
| AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance |
LC-MS/MS RNA-seq |
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| PMID: 36516775 | DOI: 10.1016/j.celrep.2022.111821 | ||
| Cell | 2021 | Research Group: YUEN Kwok Yung | CPOS Support |
| Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system |
Next Generation Sequencing (Amplicon Seq) |
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| PMID: 33713620 | DOI: 10.1016/j.cell.2021.02.053 | ||
| Cancer Cell | 2021 | Research Group: LEUNG Suet Yi | CPOS Support |
| Oncogenic mutations drive intestinal cancer initiation through paracrine remodeling |
Next Generation Sequencing (WES, WGS, RNA Seq) Single-cell RNA-seq Flow Cytometry |
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| PMID: 34256908 | DOI: 10.1016/j.ccell.2021.06.013 | ||
| Nature Microbiology | 2021 | Research Group: YEN Hui Ling | CPOS Support |
| Ancestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs | Sanger Sequencing | ||
| PMID: 34702977 | DOI: 10.1038/s41564-021-00976-y | ||
| Nature Chemistry | 2021 | Research Group: LI Xiaoyu | CPOS Support |
| Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells | Next Generation Sequencing | ||
| PMID: 33349694 | DOI: 10.1038/s41557-020-00605-x | ||
| The Journal of Clinical Investigation | 2021 | Research Group: MA Kwai Yee Stephanie | CPOS Support |
| Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma | Animal Imaging
Confocal Microscopy Flow Cytometry Mass Spectrometry Transcriptome Sequencing |
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| PMID: 33878034 | DOI: 10.1172/JCI143377 | ||
| Nucleic Acids Research | 2021 | Research Group: YUEN Wing Yee Karen | CPOS Support |
| Formation of artificial chromosomes in Caenorhabditis elegans and analyses of their segregation in mitosis, DNA sequence composition and holocentromere organization | Next Generation Sequencing (ChIP Seq) | ||
| PMID: 34417622 | DOI: 10.1093/nar/gkab690 | ||
| Nature Communications | 2021 | Research Group: GUAN Xin Yuan | CPOS Support |
| Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma |
Single-cell RNA-seq and VDJ Sequencing |
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| PMID: 33750785 | DOI: 10.1038/s41467-021-21795-z |
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| Hepatology | 2021 | Research Group: FENG Yibin | CPOS Support |
| Lysyl Oxidase‐Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis |
Flow Cytometry LC-MS/MS |
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| PMID: 33068461 | DOI: 10.1002/hep.31600 |
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| Cancer Research | 2021 | Research Group: WONG Siu Lun Alan | CPOS Support |
| A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment |
Cell Sorting Flow Cytometry RNA-seq |
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| PMID: 34666996 | DOI: 10.1158/0008-5472.CAN-21-1017 | ||
| Proceedings of the National Academy of Sciences | 2021 | Research Group: YU Cheng Han | CPOS Support |
| PI(3,4)P2-mediated membrane tubulation promotes integrin trafficking and invasive cell migration |
Bioreagent Imaging & Flow Cytometry |
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| PMID: 33947811 | DOI: 10.1073/pnas.2017645118 | ||
| Advanced Science | 2020 | Research Group: YAM Wai Ping Judy | CPOS Support |
| Nidogen 1-Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1 |
Animal Imaging Confocal Microscopy |
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| PMID: 33173740 | DOI: 10.1002/advs.202002157 | ||
